Metabolic Fate of a New Anti-ulcer Drug (+)-(1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic Acid 6-Sodium Salt Pentahydrate (TA-2711). I. Disposition, Metabolism and Protein Binding in Rats and Dogs.
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Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. I. Inactivation of enzyme protein.
To investigate the mechanism of the anti-peptic action of ecabet sodium (TA-2711) observed in pylorous-ligated rats, effects of this drug on the peptic activity of rat gastric juice, purified hog pepsin and pepsinogen were studied in vitro. After incubation with or without ecabet at acidic pH, the reaction mixture was centrifuged, and the peptic activity of the supernatant was measured. Ecabet ...
متن کاملa fundamental study of "histiriographic metafiction", and "literary genres", as introduced in "new historical philosophy", and tracing them in the works of julian barnes.
abstract a fundamental study of “historio-graphic metafiction” and “literary genres”, as introduced in “new historical philosophy”, and tracing them in the works of julian barnes having studied the two novels, the porcupine and arthur & george, by julian barnes, the researcher has applied linda hutcheon’s historio-graphic metafictional theories to them. the thesis is divided into five cha...
15 صفحه اولBis[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato]nickel(II)–aqua[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinic acid]dithiocyanatonickel(II) (1/1)
In the title cocrystal, [Ni(C(11)H(10)N(3)O(2))(2)]·[Ni(NCS)(2)(C(11)H(11)N(3)O(2))(H(2)O)], both Ni(II) ions are in disorted octa-hedral coordination environments. One Ni(II) ion is coordinated by four N atoms and two O atoms from two tridentate 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate (DPP) ligands, while the other Ni(II) ion is coordinated by a tridentate 6-((3,5-dimethyl-1H-pyrazol-1-yl))...
متن کاملDisposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism.
The role of the polymorphic cytochrome p450 2D6 (CYP2D6) in the pharmacokinetics of atomoxetine hydrochloride [(-)-N-methyl-gamma-(2-methylphenoxy)benzenepropanamine hydrochloride; LY139603] has been documented following both single and multiple doses of the drug. In this study, the influence of the CYP2D6 polymorphism on the overall disposition and metabolism of a 20-mg dose of (14)C-atomoxeti...
متن کاملEditorial: Drug Metabolism and Disposition: the biological fate of chemicals.
Renal Catabolism of Recombinant Human Soluble CD4 after Intravenous Administration to Male Sprague-Dawley Rats. TIMOThY W. HEPBURN, CHARLES B. DAVIS, JAMES J. URBANSKI, BRIAN R. SMITh, WILLIAM H. SCHAEFER, MICHAEL A. CARBONARO, AND PETER J. BUGELSKI 1044 Metabolism of Mofarotene in Hepatocytes and Liver Microsomes from Different Species: Comparison with in Vivo Data and Evaluation of the Cytoch...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1991
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.14.533